Course Title Course Code Program Level
BIOPHYSICS TIP111 Medicine B.A. / B.Sc.

Course Term
(Course Semester)
Teaching and Learning Methods
Theory Practice Lab Projects/Field Work Seminars/Workshops Other Total Credits ECTS Credits
72 36 15 87 210 5 7

Teaching Staff Prof. Dr. Ferit PEHLİVAN
Language of Instruction Türkçe (Turkish)
Type Of Course Compulsory
Prerequisites None
Recommended Optional Programme Component
Course Objectives To comprehend that the physical and chemical facts lie under the biological phenomena
Course Content The study and explanation of the living processes by physical principles, laws and concepts.
Learning Outcomes (LO) Be habited using physcal and chemical principles and laws in order to explain biological phenomena
Mode of Delivery Face to face
Course Outline
Week Topics
1. Week I: Introduction to Biophysics. Scope and Branches of Biophysics. Living Things as Open Systems
2. Week II: Basic Concepts of Molecular Biophysics. Molecular Bonds. Water and Its Importance. Proteins.
3. Week III: Bioenergetics. Laws of Thermodynamics. Entropi. Gibbs Free Energy. Kinetics of reactions.
4. Week IV: Cellular Biophysics. Structure and functions of membranes. Transport mechanisms. Resting state.
5. Week IV: Cellular Biophysics. Membrane Potential. Channel proteins. Electrical models of the membranes.
6. Week V: Action Potential. Passive Membrane Model and Core-Conductor Theory
7. Week V: Action Potential. Active Membrane Conductance and Action Potential. Voltage Clamp.
8. Week VI. Ion Channels. Patch Clamps. Voltage dependent ion channels.
9. Week VII: Compound Action Potentials. Characteristics of Nerve Fibres. Potentials in Volume Conductors.
10. Week VIII: Synaptic Transmission. Electrical and Chemical Synapse. Neuronal Integration.
11. Week IX. Basic Principles of Biological Control. Basics Control Theory. Feedback mechanesms.
12. Week X: Biophysical Basis of Electroancephalography. Characteristics of EEG waves. Evoked potentials.
13. Week XI. Skeletal Muscle. Electromyography and contraction. Hill Equation.
14. Week XII: Basis of Electrocardiography. Ionic currents in cardiac cells. Heart dipole and Einthoven Triangle.
15. Week XIII. Measuring and Recording devices. Oscilloscopes and recorders.
16. Week XIII. Measuring and Recording devices. Signal processing. Noises and filters. Digital Processing.
17. Week XIV. Bioelectric Application Devices. Biological Effects of Electric Current. Electrical Safety.
18. Week XV. Biophysics of Circulation. Hydrostatic Factor. Viscosity. Poiseuille Law.
19. Week XV. Biophysics of Circulation. Laplace law and distensibility. Heart cycle. Measuring pressure and flow.
20. Week XVI. Biophysics of Respiration. Gas laws. Surface Tension and Alveolar Mechanics. Flow of gases.
21. Week XVI. Biophysics of Respiration. Compliances and resistances. Work of respiration. Lung capacities.
22. Week XVII. Sensation. Prninciples of transduction in sensorial cells. Psychophysics. Weber-Fechner law.
23. Week XVIII. Vision. Light and image formations. Refractive errors of eye. Accomodation. Pupilla functions.
24. Week XVIII. Vision. Visual acuity and resolution. Photoreceptors and Transduction. Color vision.
25. Week XIX. Hearing. Sound and Hearing. Attributes of Sound. Intensity and frequency discrimination.
26. Week XX. Information Theory and Biology. Storage of Information. Channel capacity and senses.
27. Week XXI: Radiation Biophysics. Electromagnetic Waves, Lasers, Radioactivity and Ultrasound.
28. Week XXII. Methods of Molecular Biophysics. Spectroscopy and other methods to Identify Biomolecules.
29. Week XXIII. Medical Imaging. X Ray imaging. Computed Tomography. Positron Emission Tomography.
30. Week XXIII. Magnetic Resonance Imaging. Ultrasound imagings. Doppler methods. Ekocardiography.
31. Week
32. Week
33. Week
34. Week
35. Week
36. Week
37. Week
38. Week
Mid-term (%)
Quizes (%) 30
Homeworks/Term papers (%)
Practice (%) 10
Labs (%) 10
Projects/Field Work (%)
Seminars/Workshops (%) 10
Final (%) 40
Other (%)
Total(%) 100
Course Book (s) and/or References Pehlivan, Ferit: Biyofizik. 2. Baskı., Ankara: Hacettepe-Taş Kitabevi, 1997 Pehlivan, Ferit: Biyofizik Pratik Notları ve Raporları, Ankara: Ankara Üniversitesi Tıp Fakültesi ANTIP A.Ş. Yayınları, 1996. Glazer, Roland: Biophysics, 4th ed., Springer-Verlag, 2001. Hille, Bertil: Ionic Channels of Excitable Membranes, 2nd ed., Sinauer,1992. Aidley, David J., Stanfield, Peter R.: Ion Channels: Molecules in Action. Cambridge University Press, 1996.
Work Placement(s)
The Relationship between Program Qualifications (PQ) and Course Learning Outcomes (LO)